Rx
🏭 Serum Institute (SII)
❄️ Cold Chain
⭐ 6-in-1 Combination
🇮🇳 Made in India
🦠 Whole Cell Pertussis
Hexasiil® PFS · Serum Institute of India · 0.5 mL Single Dose PFS · Intramuscular Use · Shake Well Before Use
Full composition per 0.5 mL · Aluminium phosphate ≤1.25mg · 2-Phenoxyethanol 0.5% · Store 2–8°C · Not to be Frozen · Shake Well
🛡️ 6 Diseases Hexasiil PFS Protects Against
1
Diphtheria
Bacterial throat membrane infection — can block airways and cause heart failure. Fatal in unvaccinated children.
2
Tetanus
Lockjaw — Clostridium tetani toxin causing severe muscle spasms. No cure; prevention only through vaccination.
3
Pertussis (Whooping Cough)
Highly contagious — violent coughing fits. Deadly for infants under 6 months. Whole-cell pertussis formula is highly effective.
4
Hepatitis B
Viral liver infection causing chronic liver disease and liver cancer. HBsAg (rDNA) 15 mcg provides strong protection.
5
Poliomyelitis (IPV)
All 3 Salk strains on Vero cells — Types 1, 2 & 3. Inactivated polio vaccine delivers injectable protection alongside oral polio drops.
6
Hib (H. influenzae b)
Leading cause of bacterial meningitis and pneumonia in infants. Hib-PRP 10 mcg conjugated to Tetanus Toxoid provides T-cell dependent immunity.
💡 Why 6-in-1? Combining 6 vaccines into one injection means fewer total injections for the baby, fewer clinic/home visits, better compliance with the full immunisation schedule, and reduced anxiety for both baby and parents — while providing identical protection to 6 separate vaccines.
👥 Who Should Get Hexasiil PFS?
All Infants from 6 Weeks ⭐
Primary target: all healthy infants starting from 6 weeks of age. IAP 2024 includes 6-in-1 (DTwP-HepB-IPV-Hib) as part of the extended immunisation schedule.
Premature Babies
Preterm infants are highly vulnerable to Hib meningitis, pertussis and hepatitis B. Hexasiil is given at chronological age (6 weeks), not corrected gestational age.
Infants with Chronic Conditions
Congenital heart disease, chronic lung conditions, liver disease — these increase the severity of Hib infections and pertussis. 6-in-1 vaccination is critical for protection.
Immunocompromised Infants
HIV-exposed or HIV-positive infants, those with primary immunodeficiencies (consult doctor). Hexasiil is an inactivated vaccine — no live components, safe for immunocompromised.
Catch-Up Vaccination
Infants who missed early doses can receive catch-up vaccination. The schedule depends on age at first dose — call VacciHub for a personalised catch-up plan.
Families Preferring Indian Vaccine
Parents who prefer a trusted Made-in-India vaccine from the world's largest vaccine manufacturer (SII) at an accessible price point without compromising efficacy.
🔬 Hexasiil PFS Composition – Per 0.5 mL Dose
As per Serum Institute of India manufacturer label. Each 0.5 mL prefilled syringe contains:
| Component | Quantity | Notes |
|---|---|---|
| ACTIVE INGREDIENTS – 6 ANTIGENS | ||
| Diphtheria Toxoid | ≥ 30 IU | Adsorbed on Aluminium Phosphate |
| Tetanus Toxoid | ≥ 40 IU | Adsorbed on Aluminium Phosphate |
| B. pertussis (Whole Cell) | ≥ 4 IU | Whole-cell killed Bordetella pertussis — high immunogenicity |
| HBsAg (rDNA) | 15 mcg | Recombinant Hepatitis B surface antigen |
| INACTIVATED POLIO VACCINE (Salk strains – Vero cells) | ||
| Poliovirus Type 1 (Mahoney strain) | 40 DU | Inactivated, grown on Vero cells (Salk) |
| Poliovirus Type 2 (MEF-1 strain) | 8 DU | Inactivated, grown on Vero cells |
| Poliovirus Type 3 (Saukett strain) | 32 DU | Inactivated, grown on Vero cells |
| HIB CONJUGATE | ||
| Hib PRP (H. influenzae type b polysaccharide) | 10 mcg | Conjugated to Tetanus Toxoid (TT) carrier protein |
| Tetanus Toxoid carrier protein (Hib conjugate) | 19 to 33 mcg | T-cell dependent immunity for Hib |
| ADJUVANT, PRESERVATIVE & EXCIPIENTS | ||
| Aluminium Phosphate (Al+++) | ≤ 1.25 mg | Adjuvant — adsorbs antigens for enhanced immune response |
| 2-Phenoxyethanol | 0.5% | Preservative |
💡 Whole-Cell Pertussis (DTwP): Hexasiil uses killed whole Bordetella pertussis bacteria — the original, highly immunogenic pertussis vaccine formula used in India for decades. DTwP generates a broader antibody response than acellular pertussis (DTaP) and provides strong herd protection. It may cause more local reactions (fever, injection-site soreness) than acellular formulas — paracetamol management is recommended.
⚠️ Storage: +2°C to +8°C. NOT TO BE FROZEN. SHAKE WELL BEFORE USE. VacciHub nurses verify cold chain compliance and shake the syringe before every administration.
📅 Hexasiil PFS – IAP 2024 Immunisation Schedule
| Dose | Age | Vaccine | Notes |
|---|---|---|---|
| HEPATITIS B – BIRTH DOSE (Given Separately) | |||
| HepB Birth | At birth (within 24 hrs) | HepB monovalent (separate) | Birth dose MUST be given before starting 6-in-1 series |
| HEXASIIL PFS PRIMARY SERIES (3 DOSES) | |||
| Dose 1 | 6 Weeks | Hexasiil PFS (0.5 mL IM) | Anterolateral thigh · First 6-in-1 dose |
| Dose 2 | 10 Weeks | Hexasiil PFS (0.5 mL IM) | Minimum 4 weeks from Dose 1 |
| Dose 3 | 14 Weeks | Hexasiil PFS (0.5 mL IM) | Minimum 4 weeks from Dose 2 |
| BOOSTERS (Given as Separate Vaccines) | |||
| DTwP Booster | 15–18 Months | DTwP (not 6-in-1) or DTaP | DTP component booster only — Hib & HepB series complete |
| DT Booster 2 | 4–6 Years | DT / Tdap (pre-school) | School-entry DTP booster |
ℹ️ HepB birth dose is separate: The Hepatitis B birth dose (within 24 hours of birth) is critical and given as a monovalent HepB vaccine — not as part of the 6-in-1 series. After 3 doses of Hexasiil, the HepB primary series (total 4 doses: birth + 3 Hexasiil) is complete. No separate HepB booster needed.
⚠️ Booster vaccine: The 15–18 month booster is given as a separate DTwP or DTaP — not as another Hexasiil dose. This is because Hib and HepB series are complete after 3 primary doses. Your paediatrician will prescribe the appropriate booster vaccine.
⚙️ How Does Hexasiil PFS Work?
1
6 Antigens Delivered in One IM Injection
After shaking well, 0.5 mL is injected into the anterolateral thigh (infants). The single injection delivers Diphtheria Toxoid, Tetanus Toxoid, whole-cell B. pertussis (4IU), HBsAg rDNA (15mcg), IPV (all 3 poliovirus strains on Vero cells), and Hib-PRP conjugated to Tetanus Toxoid.
2
Aluminium Phosphate Adjuvant Depot Effect
All antigens are adsorbed on Aluminium Phosphate (≤1.25 mg Al+++). This creates a depot at the injection site — slowing antigen release and providing prolonged stimulation of antigen-presenting cells, dendritic cells and macrophages for stronger immune responses.
3
6 Independent Antibody Responses Generated
The immune system generates specific antibodies against each of the 6 antigens simultaneously: anti-Diphtheria toxoid IgG, anti-Tetanus toxoid IgG, anti-Pertussis antibodies, anti-HBs IgG, anti-poliovirus neutralising antibodies (all 3 types), and anti-PRP IgG (Hib). Memory cells for all 6 are formed.
4
Boosted After Each Dose — Mature After 3 Doses
Each dose amplifies antibody titres. After the 3-dose primary series (6–14 weeks), protective levels are achieved for all 6 diseases. The DTP booster at 15–18 months restores waning DTP immunity and consolidates long-term protection.
⚠️ Hexasiil PFS Side Effects
Hexasiil uses whole-cell pertussis (DTwP) — which causes more local and systemic reactions than acellular pertussis (DTaP). These reactions are expected and reflect the vaccine's robust immune activation.
🟡 Common (Expected with DTwP)
- 💉 Injection-site pain, redness, swelling
- 🌡️ Fever (common — may be moderate)
- 😢 Irritability / prolonged crying
- 😴 Drowsiness / poor feeding
- 🔴 Local swelling / induration at site
🔴 Rare – Seek Medical Attention
- 🤒 High fever (>39.5°C)
- 😢 Persistent crying >3 hours
- 😵 Hypotonic-hyporesponsive episode
- ⚡ Febrile seizure (rare)
- 🚨 Anaphylaxis (extremely rare)
💡 Managing DTwP reactions: Pre-emptive or post-vaccination Paracetamol (10–15 mg/kg) may be given for fever and pain as per your paediatrician's advice. Apply a cool cloth (not ice) to injection site. These reactions are generally self-limiting within 48–72 hours. Our VacciHub nurses observe babies for 30 minutes and advise parents on fever management before leaving.
⚖️ Hexasiil PFS (DTwP 6-in-1) vs Infanrix Hexa (DTaP 6-in-1)
| Feature | Hexasiil PFS (SII) | Infanrix Hexa (GSK) |
|---|---|---|
| Manufacturer | ✓ SII (India) – Largest vaccine mfr | GSK (Belgium) |
| Pertussis type | Whole cell (DTwP) | ✓ Acellular (DTaP) — fewer reactions |
| Diseases covered | 6 (D, T, wP, HepB, IPV, Hib) | 6 (D, T, aP, HepB, IPV, Hib) |
| Pertussis antigens | Whole killed bacteria – 4 IU | ✓ 3 purified antigens (PT, FHA, Pertactin) |
| Fever risk post-dose | Higher (DTwP — common) | ✓ Lower (acellular — less reactogenic) |
| Local reactions | More frequent | ✓ Fewer |
| Hib carrier protein | Tetanus Toxoid (TT) | ✓ CRM197 (same as PCV13) |
| Made in India | ✓ Yes – Pune | No – imported |
| Price | ✓ More affordable | Higher (imported) |
| IAP recommended | ✓ Yes (accepted) | ✓ Yes (preferred aP) |
| WHO immunogenicity | ✓ Strong (wP highly immunogenic) | ✓ Excellent (aP well tolerated) |
ℹ️ Which to choose? Hexasiil (DTwP 6-in-1) is effective, affordable and Made in India — excellent for families prioritising cost or availability. Infanrix Hexa (DTaP 6-in-1) has fewer fever and local reactions — preferred when tolerability is the priority. Both provide equivalent protection against all 6 diseases. Your paediatrician can advise based on your baby's specific health situation.
🚫 Precautions & Contraindications
Do NOT give Hexasiil PFS if:
- Encephalopathy within 7 days of a prior pertussis-containing vaccine
- Anaphylaxis to a prior Hexasiil dose or any component
- Acute moderate-to-severe febrile illness — defer until recovery
- Progressive neurological disorder or unstable epilepsy
Use with Caution — Discuss with Paediatrician:
- History of febrile seizures or family history of seizures
- Previous hypotonic-hyporesponsive episode after DTP
- Persistent high-pitched crying >3 hours after prior dose
- Thrombocytopenia or coagulation disorders
- Immunosuppressed infants — still recommended; immune response may be reduced
⚠️ NOT TO BE FROZEN. SHAKE WELL BEFORE USE. Do NOT inject intradermally or intravenously — intramuscular only (anterolateral thigh in infants). Do NOT mix with other vaccines in the same syringe. VacciHub nurses follow all these protocols at every home visit.
🏥 Why Book Hexasiil PFS with VacciHub?
Certified Paediatric Nurses
Trained nurses experienced in infant vaccination. Correct anterolateral thigh IM injection. Pre-vaccination health check and 30-minute post-vaccination observation.
Cold Chain — Never Frozen
Hexasiil must NEVER be frozen. Our validated cold boxes maintain exactly 2–8°C. Temperature verified before every administration.
100% Genuine SII Hexasiil
Sourced from authorised SII distributors. Batch numbers and expiry dates fully transparent on WhatsApp vaccination record.
Home Comfort for Infants
Babies are calmer at home. No hospital queues, no waiting room infections. Our nurse comes to you — the safest environment for your newborn.
Full 3-Dose Series Tracking
We track all 3 doses at 6, 10, 14 weeks and send WhatsApp reminders for each. Also remind for the 15-18 month DTP booster.
Flexible & Same-Day Slots
Morning to evening, weekends included. Multiple vaccines can be given in the same visit (at different sites) to minimise visits.
📍 Hexasiil PFS Home Vaccination – Cities We Cover
🏛️Delhi (All Areas)
🏙️Gurgaon
🌆Noida
🏘️Ghaziabad
🏗️Faridabad
🌇Greater Noida
Call +91 92050 04114 to confirm your area — same-day slots available.
❓ Frequently Asked Questions – Hexasiil PFS
Hexasiil PFS is a 6-in-1 combination vaccine by Serum Institute of India (SII). One 0.5 mL prefilled syringe protects against: (1) Diphtheria (≥30 IU toxoid), (2) Tetanus (≥40 IU toxoid), (3) Pertussis/Whooping Cough (whole cell, ≥4 IU), (4) Hepatitis B (HBsAg rDNA 15 mcg), (5) Poliomyelitis (IPV — all 3 strains on Vero cells) and (6) Hib (H. influenzae type b PRP 10 mcg conjugated to TT).
Primary series: Dose 1 at 6 weeks, Dose 2 at 10 weeks, Dose 3 at 14 weeks (intramuscular, anterolateral thigh).
HepB birth dose: Must be given within 24 hours of birth as a separate monovalent HepB vaccine before starting Hexasiil.
Booster: DTwP or DTaP booster at 15–18 months (not another Hexasiil dose — Hib and HepB series are complete after 3 primary doses).
HepB birth dose: Must be given within 24 hours of birth as a separate monovalent HepB vaccine before starting Hexasiil.
Booster: DTwP or DTaP booster at 15–18 months (not another Hexasiil dose — Hib and HepB series are complete after 3 primary doses).
Both are 6-in-1 vaccines covering the same 6 diseases. Key differences: Hexasiil uses whole-cell pertussis (DTwP) — more reactogenic (may cause more fever/local reactions) but highly immunogenic and affordable. Infanrix Hexa (GSK) uses acellular pertussis (DTaP) — fewer reactions, better tolerated but costs more. Hexasiil is Made in India (SII) while Infanrix Hexa is imported. Both are IAP-accepted. Your paediatrician can advise based on your child's health and family preference.
Yes. VacciHub provides home vaccination with genuine SII Hexasiil PFS across Delhi, Gurgaon, Noida, Ghaziabad, Faridabad and Greater Noida. Our certified nurses shake the syringe before use, administer correct IM injection, follow post-vaccination monitoring and track your 3-dose series with reminders. Call +91 92050 04114 or WhatsApp to book.
Due to whole-cell pertussis, Hexasiil commonly causes injection-site pain, redness, swelling, moderate fever, irritability and drowsiness — more frequent than acellular vaccines. These reactions are self-limiting (48–72 hours) and indicate strong immune activation. Paracetamol (10–15 mg/kg) may be given for fever/pain as per your paediatrician's advice. Serious adverse events (HHE, persistent crying, febrile seizure, anaphylaxis) are rare. Our VacciHub nurses observe babies for 30 minutes post-vaccination and advise parents on management.
Yes — absolutely critical. The Hepatitis B birth dose must be given within 24 hours of birth as a separate monovalent HepB vaccine. This protects against perinatal (mother-to-child) transmission, which is the most common route of HepB infection in India. After the HepB birth dose, the subsequent 3 doses of HepB come through the Hexasiil series at 6, 10, 14 weeks — completing the total 4-dose HepB schedule.
Hexasiil is a suspension — the aluminium phosphate adjuvant and antigens settle on standing. The vaccine must be shaken well before each use to ensure uniform suspension and correct dosing of all 6 antigens. A poorly mixed dose could result in incorrect antigen or adjuvant delivery. VacciHub nurses always shake the prefilled syringe thoroughly before administration.